January 2011

Mining Bacterial Small Molecules

As much as rainforests or deep-sea vents, the human gut holds rich stores of microbial chemicals that should be mined for their pharmacological potential.
BY L. CAETANO M. ANTUNES, JULIAN E. DAVIES AND B. BRETT FINLAY

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Same Poop, Different Gut

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The Microbial Health Factor

The Coming Health Crisis

Indirect effects of global climate change threaten the health of hundreds of millions of people. The very uncertainty that shrouds this issue must serve as an organizing principle for adaptation to its ill effects.
BY SAMUEL S. MYERS and AARON BERNSTEIN

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Warming Extinguishes Lizards

Hot Histone

Biotechnology in the Era of Climate Change

Climate Change and the Biosphere

From Simple To Complex

The switch from single-celled organisms to ones made up of many cells has evolved independently more than two dozen times.
What can this transition teach us about the origin of complex organisms such as animals and plants?
BY JEF AKST

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Earlier start to multicellular life?

Spongy Genome

MicroRNAs Found in Unicellular Alga

Surprises in Sea Anemone Genome

CONTRIBUTORS

MAIL

EDITORIAL

Brave New Drugs
Intoxicating ideas for saving a billion lives
SARAH GREENE

CRITIC AT LARGE

Garage Innovation
The potential costs of regulating synthetic biology must be counted against putative benefits.
ROB CARLSON

THOUGHT EXPERIMENT

Synthetic Spirits
Can we use science to reduce the harms of alcohol?
DAVID NUTT

NOTEBOOK

Master Collaborator
Banding together to search for a plant hormone receptor
CARRIE ARNOLD

Eau de Choice
A whiff of this mouse protein drives mate selection by females.
An F1000 Hidden Jewel
RICHARD P. GRANT

A Morbid Map
Using exome sequencing to ID genes associated with rare diseases
JEF AKST

Top 7 from F1000
A snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000

One on One: Bacterial Glue
Mélanie Hamon discusses how pathogenic bacteria manipulate gut cells during infection
CRISTINA LUIGGI

Eavesdroppings
Speaking of Science

FOUNDATIONS

The Mindless Machine, circa 1664
VANESSA SCHIPANI

PROFILE

Watt Fun!
Her doctoral advisor told her to amuse herself, and Fiona Watt has done just that—probing individual stem cells and determining the genes and molecules that direct them to differentiate or cause them to contribute to cancer.
KAREN HOPKIN

SCIENTIST TO WATCH

Jeremy Reiter
Hunting for Cilia
CRISTINA LUIGGI

BIO BUSINESS

The Profits of Nonprofit
The surprising results when drug development and altruism collide
MEGAN SCUDELLARI

THE LITERATURE

Interfering with Cancer
MicroRNAs may drive the development of leukemia.
KATHERINE HYDE AND PAUL LIU

Editor's choice in Immunology: Basophil Roles
RICHARD P. GRANT

Editor's choice in Ecology: Human Effects
RICHARD P. GRANT

Editor's choice in Developmental Biology: Myc, Nicked
RICHARD P. GRANT

LAB TOOLS

Proteins Adorned
Cracking the secrets of posttranslational modifications
AMY MAXMEN

CAREERS

Labcations
Getting to know your colleagues outside the lab makes for better science.
VANESSA SCHIPANI

READING FRAMES

Appealing Choice
A book is born from pondering why sexual selection was, for so long, a minor component of evolutionary biology.
ERIKA LORRAINE MILAM

Capsule Reviews
How to Catch a Robot Rat, by Agnès Guillot; On Fact and Fraud, by David Goodstein; Not a Chimp, by Jeremy Taylor; and Here Is a Human Being, by Misha Angrist
RICHARD P. GRANT