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The man behind the peas

"Gregor Mendel: Planting the Seeds of Genetics" lays its roots in Philadelphia


[Published 23rd May 2008 04:06 PM GMT]


In 1859, Charles Darwin wrote in On the Origin of Species that "the laws governing inheritance are quite unknown." Unknown to him maybe, but three years earlier, an obscure Augustinian friar was toiling away in his garden to discover those laws -- laws that would eventually bear his name.

By now, the legend of Mendel's pea-crossing experiments is infamous in the annals of science, but the man behind the peas remains little appreciated, if not misunderstood. Enter the Gregor Mendel: Planting the Seeds of Genetics exhibition, developed by The Field Museum in Chicago, and now on its fifth and final US stop at the Academy of Natural Sciences in Philadelphia before the artifacts return home to the Mendel Museum in Brno, Czech Republic. Mendel may have dressed as a friar, but he had the heart and mind of a scientist. With a touch of affectation, the exhibition presents a comprehensive overview of the inquisitive man who revolutionized modern biology.

Johann Mendel was born in 1822, the son of tenant farmers, and adopted the name Gregor in 1843 when he joined the Augustinian order, but not many artifacts remain from his early life. One of the exhibition's earliest documents shows Mendel's "certificate of proficiency in fruit and grape growing" from 1846: the roots of his passion for plant reproduction. He seemed less cut out for life in the parish. A letter dated October 4, 1849, from Mendel's Abbott to the local Bishop, states that Mendel was relieved of his parish duties and assigned to teach at the local middle school in Brno, where he worked for 14 years, and reportedly kept a stash of dried peas in his pocket to throw at dozing students. During that time, Mendel was also in charge of the Abbey of St. Thomas herbaria's extensive collection of dried and pressed plants, many of which are on display in the exhibit.

The exhibition's most endearing items are numerous bits of Mendel's personal scientific belongings and correspondences. Although Mendel did not have any scientific degree, he was educated at the University of Vienna, where he studied under Christian Doppler -- of the "Doppler effect" fame -- and was a diligent hands-on experimenter in a range of scientific fields, including astronomy, meteorology, and botany. From his scientific "toolbox," visitors can see his personal telescope and sunspot drawings, his brass barometer-thermometer and meteorological recordings, the 179X magnification microscope he used to precisely cross-pollinate his peas, and the garden tools he used to plant his Pisum sativum specimens.

Little remains from Mendel's infamous eight-year experiment of cultivating, crossing, and counting tens of thousands of peas. The exhibition has informative and interactive displays explaining the genetics of mendelian inheritance for young and old, but for those well-versed in Punnett squares, sadly only two fragments of Mendel's original notebooks survive from this period. There are, however, original manuscripts of his 1866 publication "Experiments in Plant Hybrdization" in Proceedings of the Natural History Society of Brünn, as well as the few publications that cited the paper over the next few decades, and the eventual "rediscovery" of his work in 1900.

Mendel's copy of Wonders of the Invisible World by Gustav Jäger, 1867
Mendel was widely versed in the science of the day, and a number of his personal books are on display, often with Mendel's comments and notations in the margin. Perhaps the most striking is Mendel's German copy of Darwin's On the Origin of Species, which the exhibition curators have left open to page 21 marked up with two dashes and an exclamation point highlighting the line: "There are so many laws regulating variation, some few of which can be dimly seen." Mendel likely read Darwin's Origin half-way through his pea experiments, so one can only speculate why he was marking the page. I like to think he was saying, "I can see the laws!"

The exhibition is padded out with a whirlwind 20th century history of genetics, from the dawn of cytology and the discovery of DNA to sequencing the human genome, and it includes many original pieces of artwork inspired by Mendel and genetics. But the show's greatest strengths are the personal touches. Toward the end of the Mendel section, we see the apiary in which he tried to replicate his pea experiments using bees toward the end of his life. As he didn't know about haplodiploidy, those experiments were doomed to failure.

After over an hour in the exhibition, I was running out of steam, but hidden away in a back corner in an unassuming little glass case, I stumbled on a pair of eyeglasses. Mendel's portrait might not be as well known as Darwin's, but to anyone who is familiar with his face, Mendel's little round spectacles are the equivalents of Darwin's beard -- a powerful symbol of modern biology and the great scientists who have uncovered its secrets. As I stared at them, I paused to marvel; these thin bits of glass are the quite literal lenses through which Mendel saw the nature of life.

Not long before Mendel died in 1884, he said to a colleague, "my time will come." Indeed it has.

Elie Dolgin
mail@the-scientist.com

Gregor Mendel: Planting the Seeds of Genetics runs from May 24 through September 28 at the Academy of Natural Sciences in Philadelphia: 1900 Benjamin Franklin Parkway, 215-299-1000.


All photos (except Mendel's eyeglasses): © Stepan Bartos


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Rating: 4.55/5 (84 votes )





Mendel Symposium Villanova Sept 21-23
by Dennis Wykoff

[Comment posted 2008-05-27 14:19:15]
In conjuction with the exhibition at the Academy of Natural Sciences, we write to inform you of the Mendel in the 21st Century Symposium: Scientific, Social and Ethical Impact of Genetics in our World (September 21-23). The event celebrates the 80th anniversary of Villanova?s granting of the Mendel Medal, which honors outstanding scientists whose work and life exemplifies the amity of true science and true religion. This free Symposium features prominent and engaging speakers in fields ranging from molecular genetics, genomics, biotechnology, and evolutionary biology, to history and philosophy of science, ethics, law, and medicine. Keynote addresses will be given by Sean B. Carroll, author of Endless Forms Most Beautiful: The New Science of Evo-Devo and the Making of the Animal Kingdom; and Kenneth R. Miller, author of Finding Darwin?s God: A Scientist?s Search for Common Ground between God and Evolution. For more information see

LINK





Correction
by Friedrich Katscher

[Comment posted 2008-05-24 02:33:06]
Of course, Mendel did not die in 1984 but in 1884.



Great funeral
by Friedrich Katscher

[Comment posted 2008-05-24 02:23:06]
I want to add some details of Mendel's biography, which generally are not known:
The abbot of the Augustine convent St. Thomas in Brno, Prelate Gregor Johann Mendel, died of nephritis, dropsy and heart failure on January 6, 1984, was buried three days later in a great funeral: High officials, professors of schools and universities, catholic clergymen, the Protestant pastor, even the high rabbi bid farewell to the always helpful and kind-hearted, highly esteemed and popular man of the church. But not one of the hundreds of participants of the pompous funeral procession had the sentiment to follow the casket of one of the greatest in the history of science.
Mendel lectured on his paper "Experiments on plant hybrids" in the Nature-exploring Society in Brno on February, 8, and March, 8, 1865. In the protocol of the proceedings we read: "Questions were not asked; a discussion did not take place."



Famous Mendel
by anonymous poster

[Comment posted 2008-05-23 15:56:38]
Though I enjoyed reading the article, I resent the choice of the word 'infamouse' to describe Mendel's experiments, especially when so little is known about the intricate details of those experiments. Like so many other giants of science, Mendel was ahead of his times.



Mendel's INFAMOUS experiments
by JAN W KOPER

[Comment posted 2008-05-23 13:26:20]
The term infamous in the article about Gregor Mendel may refer to doubts that have arisen about the way in which he "pruned" his data. I heard about them first in 1973, while studying Human Genetics. They are also mentioned in Wikipedia from where the following citation comes: "Mendel's experimental results have later been the object of considerable dispute. Fisher analyzed the results of the F2 (second filial) ratio and found them to be implausibly close to the exact ratio of 3 to 1.[4] Only a few would accuse Mendel of scientific malpractice or call it a scientific fraud ? reproduction of his experiments has demonstrated the validity of his hypothesis ? however, the results have continued to be a mystery for many, though it is often cited as an example of confirmation bias. This might arise if he detected an approximate 3 to 1 ratio early in his experiments with a small sample size, and continued collecting more data until the results conformed more nearly to an exact ratio. It is sometimes suggested that he may have censored his results, and that his seven traits each occur on a separate chromosome pair, an extremely unlikely occurrence if they were chosen at random. In fact, the genes Mendel studied occurred in only four linkage groups, and only one gene pair (out of 21 possible) is close enough to show segregation distortion; this is not a pair that Mendel studied."
However, whatever is true of this, he still was right.
Jan W. Koper



great article, none the less...
by anonymous poster

[Comment posted 2008-05-23 12:59:03]
I don't want to come off as a grinch (re above comment: infamous???).
I rated the piece a 5, and in fact have forwarded it to others!



Infamous?
by anonymous poster

[Comment posted 2008-05-23 12:58:41]
Were Mendel's experiments "infamous"? If so, there must be more to the story than I know.

Definition #1 of "infamous" in Merriam-Webster Online dictionary is "having a reputation of the worst kind : notoriously evil"



infamous???
by anonymous poster

[Comment posted 2008-05-23 12:52:27]
Why did the writer twice term Mendel's experiments with peas "infamous"? I should think "famous" is more appropriate, since infamous is defined as "having a bad reputation; of bad report; notoriously vile; detestable; as, an infamous traitor; an infamous perjurer". See LINK

Perhaps there was hesitation to use famous because Mendel's 'laws' of inheritance were subsequently shown to be simplistic and not totally accurate? That is the perhaps expected fate of many significant new discoveries...



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