Got PCR woes? We want to know.

Have you done PCR on degraded DNA fragments?

Genotyped tissue fixed for decades?

Are you trying to extract DNA from a drop of raw sewage?

If so, we want to hear from you. For an upcoming article in the Lab Tools section, we want to hear about how you've managed to get your trickiest PCR to work.

Undoubtedly, PCR has revolutionized molecular biology. The technique's inventor, Kary Mullis, was awarded the Nobel Prize just seven years after he came up with the idea. And since then, genotyping has gotten immeasurably easier. But it's not all fun and games. Sometimes PCR just doesn't work, and some types of samples invite disaster.

Leave a comment by clicking here and tell us your PCR war stories, and how you've tackled the dodgiest PCR samples you've worked with. In the coming weeks, we may use your comments or contact you for inclusion in the Lab Tools article.

The Scientist Staff
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