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by Jonathan B Weitzman
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RESEARCH ROUND-UP
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MicroRNAs
MicroRNAs in the fly genome are complementary to some 3' untranslated regions.
Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2002, 3(1):20020328-01
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Large families of RNA molecules of 21-22 nucleotides, called microRNAs, have been found in a number of species. In an Advanced Online Publication from Nature Genetics, Eric Lai from the University of California at Berkeley, describes a family of microRNAs in Drosophila (Nat Genet 2002, DOI:10.1038/ng865).
He found that 11 Drosophila microRNAs are complementary to the K-box motif (cUGUGAUa), Brd box (AGCUUUA) and GY box (uGUCUUCC) motifs present in the 3' untranslated regions (UTRs) of several basic helix-loop-helix genes (bHLH). The microRNA may bind these sequences and mediate negative post-transcriptional regulation.
The conservation of some microRNAs in man and worms will prompt work on defining a regulatory role for microRNA-3'UTR RNA duplexes.
References
| 1. | | Identification of novel genes coding for small expressed RNAs.
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[1]
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| 2. | | [http://www.nature.com/ng/]
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| | | Lai EC: Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet 2002, DOI:10.1038/ng865.
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[1]
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| 3. | | [http://www.berkeley.edu]
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| | | University of California at Berkeley
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