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by Tudor Toma
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RESEARCH ROUND-UP
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Small genomes are still shrinking
Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2002, 3(1):20020327-03
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Buchnera is a mutualistic intracellular symbiotic bacterium found in many aphids and over millions of years it has experienced a dramatic decrease in genome size, retaining only those genes essential for its specialized lifestyle. In March 19 Proceedings of National Academy of Science, Rosario Gil and colleagues from Universitat de Valencia, Spain, show that the Buchnera genome is still undergoing a reductive process.
Gil et al. performed physical mapping of Buchnera genomes obtained from five aphid lineages. They found that the genome size among different lineages is not conserved, but has been reduced down to 450 kb in some species. In addition, they showed evidence that six species of Buchnera have a genome size smaller than Mycoplasma genitalium, the smallest bacterial genome reported thus far (580 kb) (Proc Natl Acad Sci USA 2002, 10.1073/pnas.062067299).
"The sequencing of these smaller genomes will give new clues about the lost genes that are essential for bacterial growth, in an attempt to define a minimal genome [the minimum number of genes necessary to support cellular life]," suggested the authors.
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