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by Jonathan B Weitzman
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RESEARCH ROUND-UP
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Mitochondrial inheritance
Examining co-inheritance of mitochondrial and female-specific nuclear DNA supports the hypothesis of clonal inheritance.
Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2001, 2(1):20010906-01
| Published | | 6 September 2001 |
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In September 6 Nature, Sofia Berlin and Hans Ellegren from Uppsala University, Sweden, examine the controversial clonal inheritance theory for vertebrate mitochondrial DNA (mtDNA) by following co-inheritance of a female-specific nuclear DNA marker (Nature 2001, 413:37-38).
They examined the avian W chromosome, most of which is non-recombining and therefore clonally transmitted by females. A polymorphic (CA)n repeat, NVHfp49, on the W chromosome of 53 female peregrine falcons (Falco peregrinus) and 1,625 bp of mtDNA sequence were followed. The patterns of divergence of mtDNA and W-chromosome sequences were completely concordant.
These data support the hypothesis of clonal inheritance of mtDNA from mothers to daughters without recombination.
References
| 1. | | [http://www.nature.com]
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| | | Berlin S and Ellegren H: Clonal inheritance of avian mitochondrial DNA. Nature 2001, 413:37-38.
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| 2. | | [http://www.uu.se]
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| | | Uppsala University
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| 3. | | Linkage disequilibrium and recombination in hominid mitochondrial DNA.
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| 4. | | Evolution of the avian sex chromosomes and their role in sex determination.
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