Systems biology at biotechnology and pharmaceutical companies

Company

Approach

Location

Bioseek

Screen novel compounds with combinations of human primary cells to measure activity and understand their mechanism of action

Burlingame, California

Gene Network Sciences

Use models to improve quality of pre-clinical compounds and guide the design of clinical trials.? Evaluate cardiovascular safety with Visual Heart.?

Ithaca, New York

Genstruct

Apply causal-inference models to identify biomarkers for drug toxicity, drug resistance, and cardiovascular drug mechanisms.

Cambridge, Massachusetts

Rosetta Inpharmatics
(subsidiary of Merck)

Identify targets in gene networks regulating obesity, diabetes, and other phenotypic traits, using microarray techniques.

Seattle, Washington

Optimata

Use a human physiological model designed for understanding disease dynamics and optimizing drug and treatment schedules

Ramat Gan, Israel

Entelos

Use virtual patients, recently modeling skin sensitivity for the cosmetics industry.

Foster City, California

BG Medicine

Find biomarkers for diseases, treatment responses and compound safety, including liver toxicity, via pathway databases and statistical analysis of wet lab findings.

Waltham, Massachusetts

GeneGo

License pathway database, MetaCore, for analyzing functional genomics data.

St. Joseph, Michigan

Novartis

Link data from signaling pathways to bone cellular physiology and bone disease, and build models of cardiac safety.

Cambridge, Massachusetts

Pfizer Research and Technology Center

Model small molecule and biological therapies with small networks that incorporate higher-level physiological elements, like kidney function.?

Cambridge, Massachusetts

AstraZeneca

Use both cell-based assays and biosimulation to support small molecule projects and biological therapies.

Cheshire, England