Date: 2007-07-01
Papers to Watch
Y. Zhou et al., "The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis,"
Cell
, 129:163-78, Apr. 6, 2007.
This excellent paper reports a novel means of coupling cell-cycle progression with cell fate decisions. The authors show that the fragmentation of the Golgi complex, which precedes mitosis of neural progenitor cells, releases a Numb binding protein, thereby modulating cell fate decisions following asymmetric cell division.
-Mark Bothwell
C.A. Miller et al., "Covalent modification of DNA regulates memory formation,"
Neuron
, 53:857-69, Mar. 15, 2007.
During hippocampal memory formation, transient DNA methylation regulates the expression of two genes, the memory suppressor phosphatase 1 and the plasticity gene reelin. Prevention of this DNA methylation impairs memory formation.
-Karl-Peter Giese
N.B. Sutter, et al., "A single IGF1 allele is a major determinant of small size in dogs,"
Science
, 316:112-5, Apr. 6, 2007.
In this recent study, Sutter et al. identified a strong association between a single haplotype at the insulin-like growth factor 1 (IGF1) locus and small size within a specific dog breed (Portuguese water dog), and among dog breeds in general.
-Anthony Zera
These papers were selected from multiple disciplines from the Faculty of 1000, a web-based literature awareness tool (www.f1000biology.com). Advertisement
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