Table: Selected TLR Ligands in Clinical Trials

Product

Target

Manufacturer

Condition

Phase

Intervention

Status

CPG7909

TLR9

Coley Pharmaceutical Group

Lymphoma

I/II

CpG injections and radiotherapy
http://www.clinicaltrials.gov/ct/show/NCT00185965

Ongoing

ﾠ

Coley/Pfizer

Metastatic breast cancer, renal cell cancer, T-cell lymphoma, non-small cell lung cancer, melanoma

I or II

CpG injection with or without chemotherapy
http://www.clinicaltrials.gov/ct/show/NCT00043407
http://www.clinicaltrials.gov/ct/show/NCT00043420
http://www.clinicaltrials.gov/ct/show/NCT00070629
http://www.clinicaltrials.gov/ct/show/NCT00070642

Ongoing and completed

ﾠ

Malaria

Malaria vaccine with and without CpG 7909
http://www.clinicaltrials.gov/ct/show/NCT00320658

Recruiting

CPG10101

TLR9

Coley Pharmaceutical Group

Hepatitis C

Pegylated interferon plus ribavirin with or without CPG 10101 in hepatitis C patients
http://www.clinicaltrials.gov/ct/show/NCT00277238

Recruiting

ﾠ

1018 ISS

TLR9

Dynavax

Allergy

ISS conjugated to ragweed allergen given to patients with allergic rhinitis
http://www.clinicaltrials.gov/ct/show/NCT00346086

Completed

ﾠ

B-cell follicular lymphoma

ISS given in conjunction with Rituxan
http://www.clinicaltrials.gov/ct/show/NCT00251394

Recruiting

ﾠ

Metastatic colorectal cancer

ISS in combination with irinotecan and cetuximab
http://www.clinicaltrials.gov/ct/show/NCT00403052

Recruiting

ﾠ

Hepatitis B

ISS with hepatitis B surface antigen compared with commercial hepatitis vaccine
(completed in 2004; phase III trial underway in Asia)

Completed

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