By Jeffrey M. Perkel
FTICR-MS
|
|
|
|
ILLUSTRATION: ANDREW MEEHAN
|
Sporting greater mass accuracy than other mass spectrometers, Fourier transform-ion cyclotron resonance (FTICR) mass spectrometry instruments have the ability to resolve and sequence intact proteins, rather than proteolytic fragments.
Advertisement
Rate this article
Rating: 3.00/5 (2 votes )
Where's the article? by Rebut
[Comment posted 2006-10-03 20:04:44]
The article is in the diagram, you must click on the diagram to view the flash animation.
Not very in depth though, i was hoping for something a bit more experiment oriented.
Sequencing ? by Bob Dratch
[Comment posted 2006-10-03 20:04:12]
We use FT analysis regularly.
I don't see how in this article for instance base-pairs can be sequenced intact, and how one can establish any orientation or any reference starting point.
It looks like a new "spin" on an old process to me. More data in the article as to how such tech would actually be used in practice, would let us all evaluate this method that is proposed in the article.
I feel it would be great not to have to use gels or replicate.
What's the minimum amount of material recognizable for instance?
|
Register for FREE Online Access
Subscribe to the Magazine